Applied Pharmaceutical Chemistry 2009 Agenda
Theme: Frontiers in Strategies and Technologies to enrich pharmaceutical pipelines
APC is structured to loosely follow the drug discovery and development process:
Day 1
8:00 AM Check In (Merck Security)8:30 - 8:40 Conference Opening Remarks, Julian Adams (Infinity)
Lead ID Session
Approaches and Lessons in Lead ID
Moderator: Mark Goulet, Merck Research Laboratories
8:40 - 8:50 Session Opening Remarks: Mark Goulet (Merck)
8:50 - 9:20 Steve Swann, Abbott: Fragment-based discovery of novel allosteric kinase inhibitors
9:20 - 9:50 Jeffrey Albert, Astra Zeneca: Fragment-bsaed lead ID
9:50 - 10:00 Break (Coffee Served)
10:00 - 10:30 David Rees, Astex: Case histories: from fragment to clinic
10:30 - 11:00 Panel Discussion
11:00 - 11:15 Break (Coffee Served)
11:15 - 12:00 Ann Weber, Merck: Case Study 1 - Discovery of Januvia
Lead Opt Session
Approaches and Lessons in Lead Optimization
Moderator: Mark Duggan, Link Medicine
1:10 - 1:40 Mark Bilodeau, Merck Research Laboratories: Kv1.5 blockers: Invention of an ion channel selective and peripherally restricted clinical candidate
1:40 - 2:10 Travis Wager, Pfizer: Development of a CNS multi-parameter optimization (MPO) design tool increasing the probability of compound survival by aligning metabolism, permeability, and safety properties in one molecule
2:10 - 2:25 Break (Coffee Served)
2:25 - 2:55 Mark Wittman, BMS: The discovery of BMS-754807, a small molecule inhibitor of IGF-1R in clinical development
2:55 - 3:40 Panel Discussion
3:40 - 3:55 Break (Coffee Served)
3:55 - 4:40 Julian Adams, Infinity: Case Study 2 - Discovery of Velcade
Keynote Address
4:40 - 5:30 Ed Scolnick, Plenary Speaker: Insights into Psychiatric Genetics and Biology
Moderator: Julian Adams, Infinity
Day 2
8:00 AM Check In (Merck Security)New Tech Session
New Technologies & Techniques
Moderator: Youseff Benanni, Vertex
8:30 - 8:40 Youseff Benanni, Vertex, Session Introduction
8:40 - 9:10 Benjamin F. Cravatt, Scripps: Activity based profiling and its application for enzyme inhibitor discovery
9:10 - 9:40 Pat Walters, Vertex: ASAP-Emphasizing Multidimensional Drug Discovery
9:40 - 10:10 Break (Coffee Served)
10:10 - 10:40 Nick Terrett, Ensemble Discovery: A DNA-programmed chemistry approach to macrocyclic lead compounds
10:40 - 11:10 Anna Bowman, Northeastern University: Small molecule inhibitors of the MDM2-p53 interaction discovered through the multiple protein structure (MPS) method
Conference End
